在病程早期识别和治疗疾病,并且达到体重完全恢复的情况下,AN 的预后是最佳的。始终建议采取以恢复为导向的治疗,即使长期生病的患者也会恢复,但是认为较年轻患者的预后最佳。随访研究表明,约 75% 的青少年 AN 患者可完全康复,但到恢复的时间可能为 3-5 年。[69]Strober M, Freeman R, Morrell W. Long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study. Int J Eat Disord. 1997 Dec;22(4):339-60.http://www.ncbi.nlm.nih.gov/pubmed/9356884?tool=bestpractice.com 在成年患者中,快速体重恢复后的复发率高,慢性 AN(也被称为“严重持续性 AN”)可能在虽少但不可忽视的一部分就诊患者中发生。[69]Strober M, Freeman R, Morrell W. Long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study. Int J Eat Disord. 1997 Dec;22(4):339-60.http://www.ncbi.nlm.nih.gov/pubmed/9356884?tool=bestpractice.com
长期预后
一研究经过 10~ 15 年的随访显示,超过 75% 的患者会完全康复。[69]Strober M, Freeman R, Morrell W. Long-term course of severe anorexia nervosa in adolescents: survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study. Int J Eat Disord. 1997 Dec;22(4):339-60.http://www.ncbi.nlm.nih.gov/pubmed/9356884?tool=bestpractice.com 一项在 103 名患者中进行超过 12 年随访的研究显示,88% 的患者仍然存活。在这些人中,19% 仍然患有 AN,9.5% 有催吐型神经性贪食障碍,19% 有非特殊型进食障碍,52.4% 康复。研究结果显示长期结局不良的预测指标主要有 4 个:性问题、强迫、厌食期延长和长期住院治疗。一篇文献综述发现,预后不良与初始体重较低、家庭关系差、男性、催吐、对治疗无反应和症状持续时间长有关。[70]Walsh JME, Wheat ME, Freund K. Detection, evaluation, and treatment of eating disorders: the role of the primary care physician. J Gen Intern Med. 2000 Aug;15(8):577-90.http://www.ncbi.nlm.nih.gov/pubmed/10940151?tool=bestpractice.com
死亡率
与 AN 相关的死亡率很高,据估计每十年为 5%。[71]Fichter MM, Quadflieg N, Hedlund S. Twelve-year course and outcome predictors of anorexia nervosa. Int J Eat Disord. 2006 Mar;39(2):87-100.http://www.ncbi.nlm.nih.gov/pubmed/16231345?tool=bestpractice.com AN 是过早死亡率最高的精神疾病之一(过早死亡的风险约为同龄人的 5 倍)。[72]Franko DL, Keshaviah A, Eddy KT, et al. A longitudinal investigation of mortality in anorexia nervosa and bulimia nervosa. Am J Psychiatry. 2013 Aug;170(8):917-25.https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.12070868http://www.ncbi.nlm.nih.gov/pubmed/23771148?tool=bestpractice.com 死亡的主要原因是躯体并发症或自杀。[33]Rosen DS. Eating disorders in children and young adolescents: etiology, classification, clinical features, and treatment. Adolesc Med. 2003 Feb;14(1):49-59.http://www.ncbi.nlm.nih.gov/pubmed/12529190?tool=bestpractice.com[73]Hsu LKG. Outcome of early onset anorexia nervosa: what do we know? J Youth Adolesc. 1996 Aug;25(4):563-8.