BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 五月 2019

小结

定义

病史和查体

关键诊断因素

  • 存在的危险因素
  • 以往在西非和中非的农村地区待过(冈比亚锥虫病)
  • 以往在东非和南非的野生动物保护区待过(罗得西亚锥虫病)
  • 颈部淋巴结增大/温特伯顿氏征(冈比亚锥虫病)

其他诊断因素

  • 有若干次疟疾治疗史,但病情未得到改善
  • 头痛
  • 发热
  • 疲乏和全身不适

危险因素

  • 舌蝇暴露
  • 与感染冈比亚锥虫病的人员在同一个地区生活或工作
  • 与感染罗得西亚锥虫病的动物在同一个地区生活或工作

诊断性检查

首要检查

  • 全血细胞计数
  • 红细胞沉降率
  • 血清免疫球蛋白
  • 锥虫病卡片凝集试验(CATT)
全部具体信息

需要考虑的检查

  • 心电图
  • 脑脊液 (CSF) 白细胞计数
  • 脑脊液显微镜检查
  • 脑脊液二次分离
全部具体信息

新兴检查

  • 聚合酶链反应 (PCR)
  • 鞘内免疫球蛋白生产
  • 分期生物标志物
  • 免疫溶锥虫
全部具体信息

治疗流程

贡献者

Director of Research

Institut de Recherche pour le Développement

Montpellier

France

利益冲突披露
VL is an author of several references cited in this monograph. VL declares that he has no competing interests.

Medical Officer

Control of Neglected Tropical Diseases

Human African Trypanosomiasis Control Program

World Health Organization

Geneva

Switzerland

利益冲突披露
JRF is an author of several references cited in this monograph. JRF declares that he has no competing interests.

Former head of WHO HAT control and surveillance programme

WHO temporary advisor

World Health Organization

Geneva

Switzerland

利益冲突披露
PPS is an author of several references cited in this monograph.

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Professor of Molecular Parasitology and Medicine

Centre for Infection

Division of Cellular and Molecular Medicine

St. George's

University of London

London

UK

利益冲突披露
SK is a consultant for the Foundation for Innovative Diagnostics, a non-profit organization developing diagnostics for neglected diseases such as HAT. SK is an author of a reference cited in this monograph.

Professor

Division of Infection and Immunity

Institute of Biomedical and Life Sciences

The Glasgow Biomedical Research Centre

University of Glasgow

Glasgow

UK

利益冲突披露
MB declares that he has no competing interests.

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