PNH是一种罕见疾病,人群发病率为百万分之1-6,男女发病率相同,发病年龄集中于30-50岁。儿童群体中少见。全世界均有发病,发病无明显种族倾向性。但它与再生障碍性贫血贫血的发生地域相关,例如泰国农村。[1]Rosse W. Paroxysmal nocturnal hemoglobinuria as a molecular disease. Medicine (Baltimore). 1997;76:63-93.http://www.ncbi.nlm.nih.gov/pubmed/9100736?tool=bestpractice.com[2]Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709.http://www.bloodjournal.org/content/106/12/3699.fullhttp://www.ncbi.nlm.nih.gov/pubmed/16051736?tool=bestpractice.com