仅抗生素治疗
多项研究评估了仅使用抗生素与采用阑尾切除术来治疗无并发症的阑尾炎。[67]Vons C, Barry C, Maitre S, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377:1573-1579.http://www.ncbi.nlm.nih.gov/pubmed/21550483?tool=bestpractice.com[68]Styrud J, Eriksson S, Nilsson I, et al. Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg. 2006;30:1033-1037.http://www.ncbi.nlm.nih.gov/pubmed/16736333?tool=bestpractice.com[69]Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015;313:2340-2348.http://www.ncbi.nlm.nih.gov/pubmed/26080338?tool=bestpractice.com[70]D'Souza N, Nugent K. Appendicitis. BMJ Clin Evid. 2014. pii: 0408.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259213/http://www.ncbi.nlm.nih.gov/pubmed/25486014?tool=bestpractice.com[71]Rollins KE, Varadhan KK, Neal KR, et al. Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg. 2016;40:2305-2318.http://www.ncbi.nlm.nih.gov/pubmed/27199000?tool=bestpractice.com[72]Sallinen V, Akl EA, You JJ, et al. Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis. Br J Surg. 2016;103:656–667.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069642/http://www.ncbi.nlm.nih.gov/pubmed/26990957?tool=bestpractice.com 大多数研究的样本量较小,仅纳入经严格选择的没有脓毒症、穿孔或脓肿形成征象的患者。在其中大多数研究中,静脉给予抗生素 48-72 小时,然后给予口服抗生素 7-10 天。在患者接受抗生素静脉给药时,每 6 -12 小时进行连续的临床检查。如果患者在住院观察期间出现任何脓毒症、腹膜炎或休克征象,则对其进行手术。这些研究的结果没有表明仅用抗生素可以与手术一样有效治疗无并发症的阑尾炎,但表明一些患者仅通过使用抗生素就可以被成功治疗。[67]Vons C, Barry C, Maitre S, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377:1573-1579.http://www.ncbi.nlm.nih.gov/pubmed/21550483?tool=bestpractice.com[68]Styrud J, Eriksson S, Nilsson I, et al. Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg. 2006;30:1033-1037.http://www.ncbi.nlm.nih.gov/pubmed/16736333?tool=bestpractice.com 几项系统评价总结道,对于非复杂性阑尾炎,手术比抗生素治疗更有效,但是手术引起并发症的风险更高。[70]D'Souza N, Nugent K. Appendicitis. BMJ Clin Evid. 2014. pii: 0408.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259213/http://www.ncbi.nlm.nih.gov/pubmed/25486014?tool=bestpractice.com[71]Rollins KE, Varadhan KK, Neal KR, et al. Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg. 2016;40:2305-2318.http://www.ncbi.nlm.nih.gov/pubmed/27199000?tool=bestpractice.com[72]Sallinen V, Akl EA, You JJ, et al. Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis. Br J Surg. 2016;103:656–667.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069642/http://www.ncbi.nlm.nih.gov/pubmed/26990957?tool=bestpractice.com 然而,证据基础一般较弱,并且受到一些混杂因素的影响,例如,结果、诊断方案、评估的结局以及实施的手术操作类型缺乏一致性。目前,不推荐将仅使用抗生素作为急性阑尾炎的首选治疗。不过,一些无并发症的阑尾炎患者可能从初始抗生素治疗中获益。[67]Vons C, Barry C, Maitre S, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377:1573-1579.http://www.ncbi.nlm.nih.gov/pubmed/21550483?tool=bestpractice.com[68]Styrud J, Eriksson S, Nilsson I, et al. Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg. 2006;30:1033-1037.http://www.ncbi.nlm.nih.gov/pubmed/16736333?tool=bestpractice.com 需要进行进一步的大型试验。[73]Flum DR. Clinical practice. Acute appendicitis--appendectomy or the "antibiotics first" strategy. N Engl J Med. 2015;372:1937-1943.http://www.ncbi.nlm.nih.gov/pubmed/25970051?tool=bestpractice.com