由于这种疾病的典型表现(如非性兴奋状态下的持续阴茎勃起),使得阴茎异常勃起的诊断并不困难。诊断应该注意阴茎异常勃起的基础类型的性质(如缺血性、非缺血性或复发性)和鉴别导致/诱发的情况。
临床评估
当患者出现勃起时间延长的表现时,应详细了解患者的病史并仔细进行体格检查。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com[4]Berger R, Billups K, Brock G, et al; AFUD Thought Leader Panel on Evaluation and Treatment of Priapism. Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism. Int J Impot Res. 2001;13(suppl 5):S39-S43.http://www.nature.com/ijir/journal/v13/n5s/pdf/3900777a.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/11781746?tool=bestpractice.com这包括勃起时间的长短、发病前的一些相关因素、可以缓解病情的方法或临床治疗、之前阴茎异常勃起的发病情况、疼痛程度、可能与起病相关的病因或合并症、在发病以前的勃起功能情况。
对阴茎直接的体格检查可以评估勃起的长度、受累的海绵体有多少(如三条海绵体均受累)、是否有压痛和其严重程度。在缺血性阴茎异常勃起时,阴茎海绵体触诊质硬且有压痛。与之相比,非缺血性阴茎异常勃起时,阴茎无触痛且通常触诊不硬。腹部、会阴和直肠检查可以发现外伤、恶性肿瘤或盆腔感染的征象。当怀疑存在脊髓损伤时,应该做全面的神经查体。[34]Burnett AL. Priapism. In: Wein AJ, Kavoussi LR, Novick AC, et al, eds. Campbell-Walsh urology. 9th ed. Philadelphia PA: Saunders Elsevier; 2007:839-849.
实验室研究
阴茎异常勃起的所有患者应该进行FBC、白细胞计数(WBC)和分类、血小板计数等初步检查,以评估是否存在血液疾病或急性感染。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com白细胞计数可能升高,提示感染(盆腔脓肿)或血液系统疾病可能。合并镰状细胞贫血病患者可能存在贫血和网织红细胞增多症。因为血红蛋白病可能发生在不易受影响的种族中,如具有地中海血统的患者,因此对于病因不明确的患者应检查是否有镰状细胞贫血病。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com对于这些患者,如果想迅速诊断可以行镰状细胞溶解度试验。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com具有镰状细胞特性或疾病的患者通过此检查可发现镰状血红蛋白。如需进一步确认需行血红蛋白电泳检查。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com为检查是否服用精神类药物和/或违禁药物可以行尿毒物检查。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com[4]Berger R, Billups K, Brock G, et al; AFUD Thought Leader Panel on Evaluation and Treatment of Priapism. Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism. Int J Impot Res. 2001;13(suppl 5):S39-S43.http://www.nature.com/ijir/journal/v13/n5s/pdf/3900777a.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/11781746?tool=bestpractice.com[34]Burnett AL. Priapism. In: Wein AJ, Kavoussi LR, Novick AC, et al, eds. Campbell-Walsh urology. 9th ed. Philadelphia PA: Saunders Elsevier; 2007:839-849.
阴茎检查
在获得详细的病史后,海绵体血气分析可以帮助鉴别缺血性和非缺血性阴茎异常勃起。从阴茎海绵体中抽出的血可直接观察,并可以评估阴茎血液情况。[35]Lue TF, Hellstrom WJ, McAninch JW, et al. Priapism: a refined approach to diagnosis and treatment. J Urol. 1986;136:104-108.http://www.ncbi.nlm.nih.gov/pubmed/3712592?tool=bestpractice.com
[Figure caption and citation for the preceding image starts]: The technique of penile blood aspiration (corpora cavernosal needle placement for maximal corporal body irrigation).From author's clinical photo library. [Citation ends].在缺血性阴茎异常勃起的患者,抽出的血含氧量低且颜色暗淡,在非缺血性阴茎异常勃起的患者,血氧含量高而呈亮红色。海绵体血气结果可以帮助我们鉴别阴茎异常勃起的类型。缺血性阴茎异常勃起患者的海绵体血气分析显示氧分压小于30mmHg,二氧化碳分压大于60mmHg,pH小于7.25。然而非缺血性阴茎异常勃起的患者其海绵体血气分析显示氧分压大于90mmHg,二氧化碳分压小于40mmHg,pH为7.40,和室内空气环境下的正常动脉血一致。[34]Burnett AL. Priapism. In: Wein AJ, Kavoussi LR, Novick AC, et al, eds. Campbell-Walsh urology. 9th ed. Philadelphia PA: Saunders Elsevier; 2007:839-849.[2]Burnett AL, Bivalacqua TJ. Priapism: current principles and practice. Urol Clin North Am. 2007;34:631-642.http://www.ncbi.nlm.nih.gov/pubmed/17983902?tool=bestpractice.com为了比较,正常阴茎松软状态下的海绵体血气分析结果和室内空气环境下的正常混合性静脉血相似(氧分压40mmHg,二氧化碳分压50mmHg,pH7.35)。
影像学评估
彩色多普勒超声是除海绵体血气分析外的另一种诊断方式。在缺血性阴茎异常勃起的患者中,可见海绵体动脉和海绵体中的血流信号减少或消失;在非缺血性阴茎异常勃起的患者中,可见海绵体中的动脉血流信号丰富,且流速较快。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com[13]Feldstein VA. Posttraumatic "high-flow" priapism evaluation with color flow Doppler sonography. J Ultrasound Med. 1993;12:589-593.http://www.ncbi.nlm.nih.gov/pubmed/8246338?tool=bestpractice.com[2]Burnett AL, Bivalacqua TJ. Priapism: current principles and practice. Urol Clin North Am. 2007;34:631-642.http://www.ncbi.nlm.nih.gov/pubmed/17983902?tool=bestpractice.com超声相对于海绵体血气分析的另外一个好处是它可以显示解剖结构,如海绵体动脉瘘或假动脉瘤,这些都可以帮助我们进一步确认非缺血性阴茎异常勃起。通常做超声检查时患者应该呈截石位或蛙式位,这样可以首先检查会阴,然后再检查整个阴茎。如果超声会延误缺血性阴茎异常勃起的治疗时机,则不应该用超声检查代替动脉血气检测。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com[34]Burnett AL. Priapism. In: Wein AJ, Kavoussi LR, Novick AC, et al, eds. Campbell-Walsh urology. 9th ed. Philadelphia PA: Saunders Elsevier; 2007:839-849.[2]Burnett AL, Bivalacqua TJ. Priapism: current principles and practice. Urol Clin North Am. 2007;34:631-642.http://www.ncbi.nlm.nih.gov/pubmed/17983902?tool=bestpractice.com虽然阴茎动脉造影也可以显示此类血管解剖异常,但多数情况下它已被彩色多普勒超声所替代。然而,阴茎动脉造影在非缺血性阴茎异常勃起的栓塞治疗时仍发挥作用。[1]Montague DK, Jarow J, Broderick GA, et al; American Urological Association. Guideline on the management of priapism. 2003. http://www.auanet.org (last accessed 22 April 2016).http://www.auanet.org/common/pdf/education/clinical-guidance/Priapism.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14501756?tool=bestpractice.com