磷酸二酯酶-5 (PDE5) 抑制剂
与安慰剂相比，以成功性交为终点的药物总体成功率为61%-71%。[74]Brock GB, McMahon CG, Chen KK, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002 Oct;168(4 Pt 1):1332-6.http://www.ncbi.nlm.nih.gov/pubmed/12352386?tool=bestpractice.com[103]Padma-Nathan H, Steers WD, Wicker PA. Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double-blind, placebo controlled study of 329 patients. Int J Clin Pract. 1998;52:375-379.http://www.ncbi.nlm.nih.gov/pubmed/9894373?tool=bestpractice.com[104]Porst H, Rosen R, Padma-Nathan H, et al. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial. Int J Impot Res. 2001;13:192-199.http://www.ncbi.nlm.nih.gov/pubmed/11494074?tool=bestpractice.com 在性腺机能低下的患者中，睾酮替代治疗能将反应性从75%提高到85%。[105]McCullough AR, Barada JH, Fawzy A, et al. Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction. Urology. 2002;60:28-36.http://www.ncbi.nlm.nih.gov/pubmed/12414331?tool=bestpractice.com 血糖控制较好的患者较血糖控制较差的患者成功率更高(62% vs. 44%)。[106]Guay AT, Perez JB, Jacobson J, et al. Efficacy and safety of sildenafil for treatment of erectile dysfunction in a population with associated organic risk factors. J Androl. 2001;22:793-797.http://www.ncbi.nlm.nih.gov/pubmed/11545291?tool=bestpractice.com
海绵体内注射
成功率为31%-72%。[107]Porst H. The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J Urol. 1996;155:802-815.http://www.ncbi.nlm.nih.gov/pubmed/8583582?tool=bestpractice.com[108]Bennett AH, Carpenter AJ, Barada JH. An improved vasoactive drug combination for a pharmacological erection program. J Urol. 1991;146:1564-1565.http://www.ncbi.nlm.nih.gov/pubmed/1719248?tool=bestpractice.com
尿道内栓剂
报道的成功率是66%。[91]Padma-Nathan H, Hellstrom WJ, Kaiser FE, et al; Medicated Urethral System for Erection (MUSE) Study Group. Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med. 1997 Jan 2;336(1):1-7.http://www.ncbi.nlm.nih.gov/pubmed/8970933?tool=bestpractice.com
真空压缩装置
满意率波动变化范围较大(27%-74%)。[109]Hatzichristou DG, Pescatori ES. Current treatments and emerging therapeutic approaches in male erectile dysfunction. BJU Int. 2001;88(suppl 3):11-17.http://www.ncbi.nlm.nih.gov/pubmed/11578273?tool=bestpractice.com
