富血小板血浆
富血小板血浆是少量血浆中所含人血小板的自体浓缩物,已用于皱纹治疗。一项小型研究表明,富血小板血浆结合分段激光治疗可焕发老化皮肤活力。[104]Shin MK, Lee JH, Lee SJ, et al. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg. 2012;38:623-630.http://www.ncbi.nlm.nih.gov/pubmed/22288389?tool=bestpractice.com[105]Hui Q, Chang P, Guo B, et al. The clinical efficacy of autologous platelet-rich plasma combined with ultra-pulsed fractional CO2 laser therapy for facial rejuvenation. Rejuvenation Res. 2016 Jun 23 [Epub ahead of print].http://www.ncbi.nlm.nih.gov/pubmed/27222038?tool=bestpractice.com
自体纤维原细胞疗法
自体细胞疗法的高度可行性标志着美容治疗进入新阶段。在一家多中心双盲安慰剂对照试验中,具有中度至极重度鼻唇沟皱纹的成人在接受自体纤维原细胞疗法后,依据经过验证的皱纹评估量表评分,获得了 1 分的显著改善。[106]Smith SR, Munavalli G, Weiss R, et al. A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol Surg. 2012;38:1234-1243.http://www.ncbi.nlm.nih.gov/pubmed/22409385?tool=bestpractice.com目前仍需要开展更多研究来展示其安全性和药效。
1072 nm 光线
现已在研究使用 1072 nm 光线预防和治疗眼周皱纹。[107]Stirling RJ, Haslam JD. A self-reported clinical trial investigates the efficacy of 1072 nm light as an anti-ageing agent. J Cosmet Laser Ther. 2007;9:226-230.http://www.ncbi.nlm.nih.gov/pubmed/17852628?tool=bestpractice.com该疗法的理论依据是人类淋巴细胞照射进行预照射处理可对紫外线毒性提供一些防护。