近三分之二的胆管癌发生年龄50-70岁间的患者,男性发病率略高于女性。[4]Carriaga MT, Henson DE. Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer. 1995;75:171-190.http://www.ncbi.nlm.nih.gov/pubmed/8000995?tool=bestpractice.com胆管肿瘤的发病率在到2007年为止的10年间有所增加;但这些增加可能归因于数据收集和分析能力的提高。全球发病率不等。已知泰国东北部的发病率最高(>80 例/10 万人)。[1]Bridgewater J, Galle PR, Khan SA, et al; European Association for the Study of the Liver. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60:1268-1289.http://www.journal-of-hepatology.eu/article/S0168-8278%2814%2900067-1/fulltexthttp://www.ncbi.nlm.nih.gov/pubmed/24681130?tool=bestpractice.com高胆管癌发病率也见于南美国家(玻利维亚、智利)和日本北部。中等发病率出现在很多欧洲国家。美国、英国、印度、尼日利亚和新加坡的发病率较低。[5]Levin B. Gallbladder carcinoma. Ann Oncol. 1999;10(suppl 4):129-130.http://www.ncbi.nlm.nih.gov/pubmed/10436804?tool=bestpractice.com加拿大的发病率最低(0.3 例/10 万人)。[1]Bridgewater J, Galle PR, Khan SA, et al; European Association for the Study of the Liver. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60:1268-1289.http://www.journal-of-hepatology.eu/article/S0168-8278%2814%2900067-1/fulltexthttp://www.ncbi.nlm.nih.gov/pubmed/24681130?tool=bestpractice.com新墨西哥州有美国国内最高的胆道肿瘤的发病率(胆囊癌占所有肿瘤的8.5%)[6]Pitt HA, Dooley WC, Yeo CJ, et al. Malignancies of the biliary tree. Curr Probl Surg. 1995;32:1-90.http://www.ncbi.nlm.nih.gov/pubmed/7528652?tool=bestpractice.com