病死率:有中等质量证据表明,仅使用氯霉素进行治疗的患者比仅使用四环素进行治疗的患者病死率显著增加。[17]Holman RC, Paddock CD, Curns AT, et al. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437-1444.http://jid.oxfordjournals.org/content/184/11/1437.longhttp://www.ncbi.nlm.nih.gov/pubmed/11709786?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
病死率:有中等质量证据表明,仅使用氯霉素进行治疗的患者比仅使用四环素进行治疗的患者病死率显著增加。[17]Holman RC, Paddock CD, Curns AT, et al. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437-1444.http://jid.oxfordjournals.org/content/184/11/1437.longhttp://www.ncbi.nlm.nih.gov/pubmed/11709786?tool=bestpractice.com
死亡率:有中等质量证据表明,在发病后 5 天内给予患者合适的抗生素治疗可以显著降低死亡风险。[17]Holman RC, Paddock CD, Curns AT, et al. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437-1444.http://jid.oxfordjournals.org/content/184/11/1437.longhttp://www.ncbi.nlm.nih.gov/pubmed/11709786?tool=bestpractice.com[19]Kirkland KB, Wilkinson WE, Sexton DJ. Therapeutic delay and mortality in cases of Rocky Mountain spotted fever. Clin Infect Dis. 1995;20:1118-1121.http://www.ncbi.nlm.nih.gov/pubmed/7619985?tool=bestpractice.com中等质量证据还表明,死于 RMSF 的患者相比于幸存患者,开始合适抗生素治疗的时间较后者晚两天。[5]Helmick CG, Bernard KW, D'Angelo LJ. Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases. J Infect Dis. 1984;150:480-488.http://www.ncbi.nlm.nih.gov/pubmed/6491365?tool=bestpractice.com[20]Hattwick MA, Retailliau H, O'Brien RJ, et al. Fatal Rocky Mountain spotted fever. JAMA. 1978;240:1499-1503.http://www.ncbi.nlm.nih.gov/pubmed/682354?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
死亡率:有中等质量证据表明,在发病后 5 天内给予患者合适的抗生素治疗可以显著降低死亡风险。[17]Holman RC, Paddock CD, Curns AT, et al. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis. 2001;184:1437-1444.http://jid.oxfordjournals.org/content/184/11/1437.longhttp://www.ncbi.nlm.nih.gov/pubmed/11709786?tool=bestpractice.com[19]Kirkland KB, Wilkinson WE, Sexton DJ. Therapeutic delay and mortality in cases of Rocky Mountain spotted fever. Clin Infect Dis. 1995;20:1118-1121.http://www.ncbi.nlm.nih.gov/pubmed/7619985?tool=bestpractice.com中等质量证据还表明,死于 RMSF 的患者相比于幸存患者,开始合适抗生素治疗的时间较后者晚两天。[5]Helmick CG, Bernard KW, D'Angelo LJ. Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases. J Infect Dis. 1984;150:480-488.http://www.ncbi.nlm.nih.gov/pubmed/6491365?tool=bestpractice.com[20]Hattwick MA, Retailliau H, O'Brien RJ, et al. Fatal Rocky Mountain spotted fever. JAMA. 1978;240:1499-1503.http://www.ncbi.nlm.nih.gov/pubmed/682354?tool=bestpractice.com