症状改善：有高质量证据表明与安慰剂相比，婴儿双歧杆菌可更显著地改善腹痛/腹部不适、腹胀/胀气和/或排便困难。[28]Brenner DM, Moeller MJ, Chey WD, et al. The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review. Am J Gastroenterol. 2009 Apr;104(4):1033-49.http://www.ncbi.nlm.nih.gov/pubmed/19277023?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
症状改善：有高质量证据表明与安慰剂相比，婴儿双歧杆菌可更显著地改善腹痛/腹部不适、腹胀/胀气和/或排便困难。[28]Brenner DM, Moeller MJ, Chey WD, et al. The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review. Am J Gastroenterol. 2009 Apr;104(4):1033-49.http://www.ncbi.nlm.nih.gov/pubmed/19277023?tool=bestpractice.com
治疗应答：有中等质量证据表明鲁比前列酮（lubiprostone）对便秘为主的IBS患者而言，比安慰剂显著提升总体治疗应答百分比。[39]Drossman DA, Chey WD, Johanson JF, et al. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther. 2009 Feb 1;29(3):329-41http://www.ncbi.nlm.nih.gov/pubmed/19006537?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
治疗应答：有中等质量证据表明鲁比前列酮（lubiprostone）对便秘为主的IBS患者而言，比安慰剂显著提升总体治疗应答百分比。[39]Drossman DA, Chey WD, Johanson JF, et al. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther. 2009 Feb 1;29(3):329-41http://www.ncbi.nlm.nih.gov/pubmed/19006537?tool=bestpractice.com
症状改善：中等质量证据表明，5-HT3 拮抗剂阿洛司琼和西兰司琼在整体改善 IBS 症状方面比美贝维林或安慰剂更为有效。[45]Andresen V, Montori VM, Keller J, et al. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol. 2008 May;6(5):545-55.http://www.ncbi.nlm.nih.gov/pubmed/18242143?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
症状改善：中等质量证据表明，5-HT3 拮抗剂阿洛司琼和西兰司琼在整体改善 IBS 症状方面比美贝维林或安慰剂更为有效。[45]Andresen V, Montori VM, Keller J, et al. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol. 2008 May;6(5):545-55.http://www.ncbi.nlm.nih.gov/pubmed/18242143?tool=bestpractice.com
