Wilson 病在世界上的发病率约为每百万人中有 30 例。[8]Dedoussis GV, Genschel J, Sialvera TE, et al. Wilson disease: high prevalence in a mountainous area of Crete. Ann Hum Genet. 2005;69:268-274.http://www.ncbi.nlm.nih.gov/pubmed/15845031?tool=bestpractice.com Wilson 病影响约 1/30,000-1/40,000 的新生儿。[9]Brewer GJ. Wilson's disease: a clinician's guide to recognition, diagnosis, and management. Boston, MA: Kluwer Academic Publishers, 2001.[10]Hoogenraad TU. Wilson's disease. London, UK: Saunders, 1996.[11]Scheinberg IH, Sternlieb I. Wilson's disease. In: Smith LHJ, ed. Major problems in internal medicine. Vol 23. Philadelphia, PA: WB Saunders, 1984:1-171. 如果在美国所有的患者都得到诊断且具有正常的寿命,在理论上美国将有 7500-10000 位患者。该病并不偏向于特别的性别,而各民族的发病率相同。临床症状常发生于 10-40 岁左右。[12]Ala A, Borjigin J, Rochwarger A, et al. Wilson disease in septuagenarian siblings: raising the bar for diagnosis. Hepatology. 2005;41:668-670.http://www.ncbi.nlm.nih.gov/pubmed/15723329?tool=bestpractice.com