主动脉瓣反流较主动脉瓣狭窄和二尖瓣反流少见。一项美国的研究表明主动脉瓣反流在男性和女性的发病率分别为13%和8.5%,多数为微量或轻度反流;非裔美国人的发病率为15.6%。[4]Fox ER, Wilson RS, Penman AD, et al. Epidemiology of pure valvular regurgitation in the large middle-aged African American cohort of the Atherosclerosis Risk in Communities study. Am Heart J. 2007;154:1229-1234.http://www.ncbi.nlm.nih.gov/pubmed/18035099?tool=bestpractice.com无论男女,随年龄增长,主动脉瓣反流的发病率增加。[5]Singh JP, Evans JC, Levy D, et al. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). Am J Cardiol. 1999;83:897-902.http://www.ncbi.nlm.nih.gov/pubmed/10190406?tool=bestpractice.com
55岁以上无症状的人群中,超声心动图显示13%的人有中重度主动脉瓣反流,总体发病率为29%(包括轻度反流)。[6]Lindroos M, Kupari M, Heikkila J, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21:1220-1225.http://www.ncbi.nlm.nih.gov/pubmed/8459080?tool=bestpractice.com一项多中心前瞻性的流行病学研究表明在23岁至35岁的健康青年人中主动脉瓣反流的发病率为1.3%。本病发病率没有性别或种族的差异。[7]Reid CL, Anton-Culver H, Yunis C, et al. Prevalence and clinical correlates of isolated mitral, isolated aortic regurgitation, and both in adults aged 21 to 35 years (from the CARDIA study). Am J Cardiol. 2007;99:830-834.http://www.ncbi.nlm.nih.gov/pubmed/17350376?tool=bestpractice.com