与横纹肌溶解症的病因相同,即重度 5-羟色胺中毒不加治疗。患者发展为多器官衰竭,伴弥漫性血管内凝血,急性肾功能衰竭并逐步累及其他器官。及早治疗重度 5-羟色胺中毒可预防以上情况的发生。[10]Isbister GK, Hackett LP, Dawson AH, et al. Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity. Br J Clin Pharm. 2003;56:441-450.http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2003.01895.x/fullhttp://www.ncbi.nlm.nih.gov/pubmed/12968990?tool=bestpractice.com[25]Neuvonen PJ, Pohjola-Sintonen S, Tacke U, et al. Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses. Lancet. 1993;342:1419.http://www.ncbi.nlm.nih.gov/pubmed/7901695?tool=bestpractice.com[27]Power BM, Pinder M, Hackett LP, et al. Fatal serotonin syndrome following a combined overdose of moclobemide, clomipramine and fluoxetine. Anaesth Intensive Care. 1995;23:499-502.http://www.ncbi.nlm.nih.gov/pubmed/7485947?tool=bestpractice.com
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