奥马珠单抗
这是一种针对 IgE 的人源化单克隆抗体，可阻止 IgE 与效应细胞上的受体结合。尽管已接受了长期的规范治疗，但是仍有哮喘加重的变应性哮喘患者仍可使用奥马珠单抗。在皮质类固醇依赖性囊性纤维化的儿童中使用奥马珠单抗治疗 ABPA，结果显示可减少皮质类固醇用量，伴有临床症状改善。[62]Zirbes JM, Milla CE. Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis. Pediatr Pulmonol. 2008;43:607-610.http://www.ncbi.nlm.nih.gov/pubmed/18433040?tool=bestpractice.com[63]Kanu A, Patel K. Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab). Pediatr Pulmonol. 2008;43:1249-1251.http://www.ncbi.nlm.nih.gov/pubmed/19009619?tool=bestpractice.com[64]van der Ent CK, Hoekstra H, Rijkers GT. Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax. 2007;62:276-277.http://www.ncbi.nlm.nih.gov/pubmed/17329558?tool=bestpractice.com在哮喘和 ABPA 患者中使用奥马珠单抗的临床试验证实哮喘加重和口服皮质类固醇用量减少，但是在一项研究中，奥马珠单抗未能改善肺活量。[65]Moss RB. The use of biological agents for the treatment of fungal asthma and allergic bronchopulmonary aspergillosis. Ann N Y Acad Sci. 2012;1272:49-57.http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06810.x/fullhttp://www.ncbi.nlm.nih.gov/pubmed/23231714?tool=bestpractice.com[66]Lötvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127:355-360.http://www.jacionline.org/article/S0091-6749(10)01858-0/fulltexthttp://www.ncbi.nlm.nih.gov/pubmed/21281866?tool=bestpractice.com
