普来可那利
一种新型衣壳抑制剂,有抗肠病毒活性,肠病毒是多数病毒性脑膜炎病例的病因。不能用于鼻病毒感染(普通感冒),在病毒性脑膜炎评估中未显示出优于安慰剂。参与者少,且后来出现了肠病毒感染,让试验变得复杂。[2]Desmond RA, Accortt NA, Talley L, et al. Enteroviral meningitis: natural history and outcome of pleconaril therapy. Antimicrob Agents Chemother. 2006;50:2409-2414.http://aac.asm.org/cgi/content/full/50/7/2409http://www.ncbi.nlm.nih.gov/pubmed/16801419?tool=bestpractice.com[50]Abzug MJ, Cloud G, Bradley J. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J. 2003;22:335-341.http://www.ncbi.nlm.nih.gov/pubmed/12690273?tool=bestpractice.com