沙立度胺
沙立度胺一直用于缓解皮损疼痛,但是因其有致畸性,所以使用受限。[16]Van Veen NH, Lockwood DN, van Brakel WH, et al. Interventions for erythema nodosum leprosum. Cochrane Database Syst Rev. 2009;(3):CD006949.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006949.pub2/fullhttp://www.ncbi.nlm.nih.gov/pubmed/19588412?tool=bestpractice.com[17]Wu JJ, Huang DP, Pang KR, et al. Thalidomide: dermatological indications, mechanisms of action and side-effects. Br J Dermatol. 2005;153:254-273.http://www.ncbi.nlm.nih.gov/pubmed/16086735?tool=bestpractice.com
硫唑嘌呤
硫唑嘌呤是免疫抑制药,有治疗结节性红斑成功的报道。[18]Verma KK, Srivastava P, Minza A, et al. Role of azathioprine in preventing recurrences in a patient of recurrent erythema nodosum leprosum. Lepr Rev. 2006;77:225-229.http://www.ncbi.nlm.nih.gov/pubmed/17172003?tool=bestpractice.com在开始使用该药前,应检查硫代嘌呤甲基转移酶水平,并且必须在治疗期间定期监测肝功能和全血细胞计数。无法定期随访和检查的患者,不应该使用本药。[19]Meggitt SJ, Anstey AV, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011. Br J Dermatol. 2011;165:711-734.http://www.ncbi.nlm.nih.gov/pubmed/21950502?tool=bestpractice.com